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Registry Index
Updated Jan 5, 2026Clinical Standard

Vaccine Safety Registry

Hepatitis A Vaccine Safety

Professional safety data on Hepatitis A vaccines. Clinical trial outcomes, manufacturer formulations (Havrix, Vaqta), and long-term surveillance metadata.

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Clinical Overview

Professional summary

Hepatitis A is a significant liver disease induced by the Hepatitis A Virus (HAV). HAV transmission occurs primarily through the fecal-oral route, often via contaminated water or food modules.

Pathology ranges from mild, self-limiting illness to severe clinical hepatic failure lasting several months. While pediatric cohorts may present as asymptomatic, they serve as critical nodes for viral transmission.

Hepatitis A vaccine is a safe, effective tool for preventing HAV-induced hepatic pathology.
The vaccine is highly effective in preventing both individual disease and community outbreaks.
Routine pediatric vaccination is recommended starting at 12-23 months of age.
Two-dose series ensures durable long-term immunological memory.

Vaccine Formulations

Module specifics & formulations

Formulation Node

Havrix

GlaxoSmithKline

  • Authorized for cohorts 12 months +.
  • Pediatric: 720 ELISA units / 0.5 mL.
  • Adult: 1440 ELISA units / 1.0 mL.
  • Interval: 2-dose series (6-12 months).

Formulation Node

Vaqta

Merck & Co.

  • Authorized for cohorts 12 months +.
  • Pediatric: 25 units / 0.5 mL.
  • Adult: 50 units / 1.0 mL.
  • Interval: 2-dose series (6-18 months).
Prescribing Reference: View detailed composition and titration analysis on official nodes.

Clinical Triage

Eligibility & contraindications

Routine Protocol

  • Pediatric cohorts (12-23 months)
  • Catch-up immunization (2-18 years)

High-Risk Adult Triage

  • International travelers to endemic zones
  • Men who have sex with men (MSM)
  • Illicit drug users (injection/non-injection)
  • Chronic liver disease patients

Absolute & Relative Contraindications

  • Hypersensitivity to previous Hepatitis A dose
  • Acute moderate-to-severe febrile illness
  • Known allergies to registry module components

Adverse Events

Reported reactions & surveillance

Local Reactions

  • Injection site pain
  • Localized erythema
  • Induration (Swelling)

Systemic Profile

  • Generalized fatigue
  • Cephalalgia (Headache)
  • Low-grade pyrexia
  • Anorexia (Loss of appetite)
Critical Vigilance: Severe anaphylaxis is statistically exceptional. Seek intervention for angioedema, respiratory distress, urticaria, or tachycardia.

Surveillance Analytics

Post-market surveillance metrics

1995

Registry Entry

25+ Years

Surveillance Data

Millions

Doses Synchronized

Institutional Surveillance

Decades of VAERS data and active surveillance studies confirm an exemplary safety profile across all global recommended cohorts.

Editorial Governance

Clinical Reviewers & Authors

SI
Lead Hepatology Author

Dr. Sanjay Iyer

MBBS, MD (General Medicine), DM (Gastroenterology)

Gastroenterology & Hepatology

RS
Clinical Reviewer

Dr. Ritu Saxena

MBBS, MD (Community Medicine), MPH

Public Health

All vaccine safety monographs are authored and reviewed by credentialed medical specialists in infectious disease, immunology, and pediatrics.

Browse All Clinical Authors & Medical Reviewers Directory

Evidence Base

Authoritative References & Clinical Citations

The clinical guidance, contraindications, and safety surveillance statistics in this monograph are synthesized directly from authoritative public health agencies, regulatory package inserts, and peer-reviewed clinical studies:

  1. 1
  2. 2
    WHO2024
    WHO position paper on hepatitis A vaccines — June 2022

    Weekly Epidemiological Record, 97(40):493-512

  3. 3
    FDA2024
    HAVRIX and VAQTA Prescribing Information & Safety Profile

    U.S. Food and Drug Administration CBER

Verified Source Alignment:

Authored by Dr. Sanjay Iyer and clinically reviewed by Dr. Ritu Saxena, in alignment with HCP Connect Clinical Reviewers & Authors Directory. Content verified against 2026 CDC ACIP and WHO safety protocols.

Content Licensing: Available for non-commercial clinical, academic, and educational reuse under CC BY-NC-ND 4.0.

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Stated Response Policy

Vaccine Safety Enquiries & Direct Response

HCP Connect welcomes clinical questions, public health inquiries, and feedback regarding our vaccine safety monographs. Our clinical editorial staff and medical reviewers actively monitor all incoming communications.

Guaranteed Enquiry Response Timeline

We commit to responding in writing to all clinical and public enquiries within 2–3 business days (guaranteed within 5 calendar days, well within the 10 calendar day international assessment standard). Urgent clinical sourcing corrections are triaged within 24 hours.

Submit An EnquiryHepatitis A