The Weekly Roundup for October 31, 2025: Recent Publications in Women’s Mental Health

PMS AND PMDD

No articles this week

INFERTILITY AND MENTAL HEALTH

No articles this week

PSYCHIATRIC ILLNESS DURING PREGNANCY

Evaluating Bias-Mitigated Predictive Models of Perinatal Mood and Anxiety Disorders. Wong EF, Saini AK, Accortt EE, Wong MS, Moore JH, Bright TJ. JAMA Netw Open. 2024 Dec 2;7(12):e2438152.

PMAD prediction models, trained to EHR data, showed modest performance and avoided amplifying health disparities in screening and care.

MEDICATIONS AND PREGNANCY

Maternal and offspring outcomes associated with prescribed ADHD medication in pregnancy: a systematic review. Tai S, Patel S, Downes K, Rogers J, Chu-Han Huang H. Arch Womens Ment Health. 2025 Oct 14.

Twelve cohort studies were reviewed, revealing heterogeneity in outcomes and limited evidence for specific risks associated with ADHD medication use in pregnancy.

Methylphenidate and Atomoxetine in Pregnancy and Possible Adverse Fetal Outcomes: A Systematic Review and Meta-Analysis. di Giacomo E, Confalonieri V, Tofani F, Clerici M. JAMA Netw Open. 2024 Nov 4;7(11):e2443648.

Meta-analysis suggests that continuing methylphenidate or atomoxetine during pregnancy does not significantly raise the risks for congenital anomalies or miscarriage.

POSTPARTUM PSYCHIATRIC ILLNESS

Postpartum Psychosis and Bipolar Disorder: Review of Neurobiology and Expert Consensus Statement on classification. Bergink V, Akbarian S, Byatt N, Chandra PS, Cirino N, Dazzan P, De Witte L, Di Florio A, Dolman C, Jones I, Kamperman A, Mahjani B, Meltzer-Brody S, Munk-Olsen T, Nagle-Yang S, Osborne LM, Rasgon N, Robakis T, Thippeswamy H, Vigod SN, Payne JL. Biol Psychiatry. 2025 Oct 22.

An expert panel recommends that postpartum psychosis be reclassified as a distinct diagnosis under bipolar disorders in DSM and ICD.

Postpartum psychosis should be recognised as a distinct disease | King’s College London International recommendations now advocate for postpartum psychosis to be recognized as a distinct category in medical coding systems.

New Blood Test Reveals Over 80% Accurate Prediction of Postpartum Depression Risk, Offering Hope to New Mothers A new risk prediction blood test for postpartum depression shows over 80% accuracy, offering possibilities for early intervention.

Depression at 2 Months Postpartum: Results From the French National Perinatal Survey. Doncarli A, Demiguel V, Le Ray C, Deneux-Tharaux C, Lebreton E, Apter G, Boudet-Berquier J, Chantry AA, Crenn-Hebert C, Vacheron MN, Regnault N, Tebeka S. J Clin Psychiatry. 2025 Oct 8;86(4):25m15818.

Prevalence of PPD at 2 months was 16.7%. Risk factors: maternal age ?29 or ?40, North African origin, low health literacy, psychiatric history, limited social support, emotional symptoms during pregnancy, and instrumental delivery.

Prevalence of anxiety symptoms and associated factors at 2 months postpartum, results from a 2021 French national prospective cohort study. Doncarli A, Demiguel V, Le Ray C, Deneux-Tharaux C, Lebreton E et al. Eur Psychiatry. 2024 Dec 27;67(1):e89.

Postpartum anxiety symptoms affected 27.6% of mothers at 2 months. Higher risk linked to younger age, poor health literacy, psychological history, pregnancy complications, minimal weight changes, multiple ER visits, and poor pain management during delivery.

Parents Post-NICU Face Greater Perinatal Mental Health Risks NICU parents are shown to be 74% more likely to experience perinatal mood disorders in comparison to parents of healthy infants.

PSYCHOLOGICAL & NONPHARMACOLOGICAL INTERVENTIONS

Effectiveness of Psychological Therapies for Depression During the Perinatal Period: A Systematic Review and Meta-analysis. Couch E, Mai HJ, Kanaan G, Caputo EL, Lewis O, Zahradnik ML, Howard M, Bohlen LC, Konnyu K, Balk EM. Ann Intern Med. 2025 Nov 4.

CBT, behavioral activation, and IPT are effective treatment options for perinatal depression, according to a comprehensive meta-analysis.

Technology-assisted cognitive-behavioral therapy for perinatal depression delivered by lived-experience peers: a cluster-randomized noninferiority trial. Rahman A, Malik A, Nazir H, Zaidi A, Nisar A, Waqas A, Atif N, Gibbs NK, Luo Y, Sikander S, Wang D. Nat Med. 2025 Jul;31(7):2196-2203.

A digital version of the WHO ‘Thinking Healthy Programme’ (THP-TAP) delivered by trained peers offers an effective, scalable option for perinatal depression care.

The Impact of Online Mindfulness Interventions on Postpartum Depression: A Systematic Review and Meta-Analysis. Liu Q, Yuan J, Shi S, Du M, Jiang Y. Int J Ment Health Nurs. 2025 Aug;34(4):e70085.

Online mindfulness-based interventions hold promise for reducing postpartum depressive symptoms.

The Effects of Online Cognitive Behavioral Therapy on Postpartum Depression: A Systematic Review and Meta-Analysis. Pan J, Luo W, Zhang H, Wang Y, Lu H, Wang C, Li C, Fu L, Hu Y, Li Y, Shen M. Healthcare (Basel). 2025 Mar 21;13(7):696.

Online CBT is effective for decreasing postpartum depression symptoms.

Different psychological interventions for perinatal depression: a systematic review and meta-analysis of randomized controlled trials. Hua G, Yue K, Zhu Y, Yang F, Zhou M. BMC Psychiatry. 2025 Oct 14;25(1):981.

Multiple psychological treatments, including CBT and IPT, are effective for perinatal depression.

A Systematic Review of Factors Associated With Treatment Engagement and Outcome for Women in the Perinatal Period Receiving Individual Cognitive Behavioral Therapy (CBT) for Depression, Anxiety, and Trauma-Related Disorders. Simon NA, Evans J, Bispham D, Williams F, Jones J, Roberts NP, Waters CS. Depress Anxiety. 2025 Sep 18.

Systematic review reveals multiple factors shape treatment engagement and CBT outcomes in perinatal women with depression, anxiety, and trauma.

Non-pharmacological interventions for perinatal depression and anxiety among adolescent mothers: A systematic review and meta-analysis. Mwita M, Dewey D, Konje ET, Patten S. J Affect Disord. 2025 Jun 15;379:168-175.

Several psychosocial interventions show benefit for adolescent perinatal depression and anxiety.

The efficacy of antenatal Cognitive Behavioural Therapy for antenatal and postnatal depression: A PRISMA based systematic review and meta-analysis. Dooley RL, McAloon J. J Affect Disord. 2025 May 1;376:225-240.

CBT is effective for both antenatal and postnatal depression according to PRISMA meta-analysis.

Effects of Nonpharmacological Interventions on Stress, Anxiety, and Depression of Pregnant Women: A Systematic Review and Network Meta-Analysis. De?irmenci F, Ambarcio?lu Kisaçam KP, Vefikuluçay Yilmaz D. Worldviews Evid Based Nurs. 2025 Jun;22(3):e70034.

Network meta-analysis shows a variety of nonpharmacological approaches may reduce stress, anxiety, and depression in pregnancy.

PERINATAL SUBSTANCE USE

Maternal Prenatal Cannabis Use and Child Autism Spectrum Disorder. Avalos LA, Shenkute M, Alexeeff SE, Oberman N, Croen LA, Davignon M, Adams SR, Ansley D, Castellanos C, Young-Wolff KC. JAMA Netw Open. 2024 Oct 1;7(10):e2440301.

Large, adjusted cohort data show no association between maternal prenatal cannabis use and autism risk in offspring.

Early pregnancy cannabis use high in states with recreational legalization Data from California indicate rising rates of cannabis use in pregnancy after recreational legalization, underscoring the need for ongoing surveillance.

MATERNAL MENTAL HEALTH AND CHILD OUTCOMES

Maternal and Infant Outcomes for Women Experiencing Homelessness Before and During Pregnancy: A Retrospective Cohort Study. Geddes-Barton D, Goldacre R, Luchenski S, Daniels C, et al. BJOG. 2025 Oct 10.

Homelessness before and during pregnancy is linked to higher rates of severe maternal morbidity, preterm birth, and small for gestational age infants, especially among White and Asian women.

Effects of Parental Severe Mental Disorders on All-Cause and Suicide Mortalities in Adolescents and Young Adults With Major Depressive Disorder Offspring mortality linked to parental psychiatric diagnoses included paternal alcohol use disorder and maternal severe mental illnesses. Suicide risk was particularly elevated with maternal schizophrenia or bipolar disorder.

MENOPAUSE AND MENTAL HEALTH

No articles this week

OTHER TOPICS IN WOMEN’S MENTAL HEALTH

Prevalence of Life Stressors and Posttraumatic Stress Disorder Among Women in Iceland. Thordardottir EB, Song H, Shen Q, Bjornsson A et al. JAMA Netw Open. 2024 Dec 2;7(12):e2449430.

In a large Icelandic cohort, 40% of women reported lifetime exposure to sexual or physical assault, which were most strongly associated with elevated PTSD prevalence.